Drug-Excipient Compatibility Studies In Binary Mixtures of Tadalafil by Using DSC, TGA and FTIR

Objective: During drug preformulation studies, thermal analysis and spectroscopic techniques are used to detect physical or chemical incompatibilities between the active compound excipients in formulation, demonstrate safety and/or efficacy of final product. It has revolutionized erectile dysfunction with development a selective cyclic guanosine monophosphate-specific PDE-5 inhibitors. Tadalafil is one these Excipients included dosage forms assist manufacture, absorption application. Although considered be pharmacologically inert, may impair effectiveness. Material Method: DSC, TGA, FTIR, were work. Ascorbic acid, butylated hydroxyanisole, calcium phosphate dibasic, cellulose, magnesium stearate, mannitol, sodium carboxymethyl sucrose, talc, starch, primojel, citric acid exhibit interaction Tadalafil. Binary mixtures drug:excipient have been analyzed. Results: Based on results; incompatible ascorbic acid. Conclusion: Studies investigate drug-excipient compatibility an important step studies. Thermal widely such